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Multiple extracellular stimuli can kick off the serial phosphorylation from MAP kinase kinase kinase (MAPKKK) to MAP Kinase.143 However, the linker region of Smad protein is the platform for integrating MAPK/RTK signal with the TGF-β/BMP pathway.
The MAPK are a family of kinases that have been shown to be activated following multiple extracellular stimuli [33,34], with effects controlling cellular growth and differentiation [35-37] [35-37]
At any moment, a cell may experience multiple extracellular stimuli and these signals are processed by the complex intracellular network to determine the cellular response.
Nuclear translocation of NF-κB is induced by multiple extracellular stimuli that trigger activation of an IκB kinase (IKK) complex, which phosphorylates the IκBs leading to their ubiquitination and proteasomal degradation.
Multiple extracellular stimuli can kick off the serial phosphorylation from MAP kinase kinase kinase (MAPKKK) to MAP Kinase.
Multiple extracellular stimuli can initiate a cascade of serial phosphorylation activation from MAP kinase kinase kinase (MAPKKK) to MAP kinase kinase (MAPKK) and finally MAPK.
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PDK1 is a vital regulator in multiple extracellular stimuli-mediated pathways and has a role in Akt activation.
The AKAP-PKA-R interaction functions to sequester PKA in the vicinity of its phosphorylation substrates [ 2, 8, 9] and this selective concentration of PKA activity in part, explains how multiple diverse extracellular stimuli can result in highly specific and discrete PKA-mediated phosphorylation events [ 10, 11].
THOC5 is phosphorylated by several protein kinases at multiple residues upon extracellular stimuli.
THOC5 is phosphorylated at multiple positions by extracellular stimuli, such as stimulation with growth factors/cytokines/chemokines, or DNA damage.
In contrast to caspase-3, which integrates multiple endogenous and extracellular stimuli, caspase-8 is specifically activated within the death receptor-induced signalling complex (DISC).
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multiple extracellular proteases
multiple extracellular determinants
multiple external stimuli
multiple extracellular domains
multiple extracellular signalings
multiple extracellular functions
multiple extracellular factors
multiple extracellular ligands
multiple extracellular peptidases
multiple visual stimuli
multiple apoptotic stimuli
multiple extracellular metabolites
multiple extracellular chitinases
multiple extracellular signals
multiple extracellular mechanisms
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