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Multiple external stimuli can be tackled by simply adding new terms with additional inputs I inj, j ( x, t ) to Eq. (13).
Multiple external stimuli induce CREB activation via several kinase pathways, including stress pathways.
Smad4 functions as an integrator of cellular responses to multiple external stimuli.
We speculate that networking of this type may be essential to allow the cell to discern which course to commit to in the case of exposure to multiple external stimuli.
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Therefore, small metabolites generated in anabolic and catabolic processes can integrate multiple external and internal stimuli and transfer information on the energetic state of a cell to the transcriptional machinery by regulating the activity of chromatin-modifying enzymes.
It has been previously proposed that grain boundary can be treated as a two-dimensional phase in materials with possible transformations between its multiple metastable states under external stimuli such as high temperature.
Nature's materials are structured at multiple length-scales, allowing organisms to adapt to external stimuli for given (even multiple) functions.
Directed evolution formats take advantage of the dynamic structures of genomes and genomic sub-structures and their ability to evolve in multiple directions in response to external stimuli.
Cell migration is a highly complex process, regulated by multiple genes, signaling pathways and external stimuli.
Similarly, functional imaging often leads to multidimensional data sets containing partial or full information on properties of interest, acquired as a function of multiple parameters (time, temperature, or other external stimuli).
Transcription factors are the integrators of multiple signaling pathways, converting internal and external stimuli into changes in gene expression.
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