The significance threshold was p < 0.05 FDR-corrected for multiple comparisons; extent threshold was 8 voxels; voxel size was 2 × 2 × 2 mm.
Remote sensing offers unique perspectives to study the relationship between urban systems and climate change because it provides spatially explicit and synoptic views of the landscape that are available at multiple grains, extents, and over time.
To minimize false-positive findings, T maps were interrogated at a peak voxel threshold of p height = 0.005 (uncorrected for multiple comparisons) and extent threshold k E > 200 voxels (1.6 mm3), unless smaller clusters were neurobiologically plausible and relevant in the light of a priori knowledge (smaller clusters are indicated with a superscript letter a in Table 2).
Therefore, for patients who received HIV care in multiple facilities, the extent to which indicated care was received may have been underestimated.
To what extent multiple endogenous genes could be regulated simultaneously has not been explored.
It is not clear to what extent multiple PREs may be functionally redundant at their endogenous loci.
Whereas it is intuitive to expect ORF fragmentation in a draft genome due to the existence of multiple contigs, the extent of this problem is currently unknown.
In our case, we used a conservative height threshold of P <0.001 uncorrected when calculating the correction for multiple comparisons in extent across the whole brain.
In statistical parametric mapping (SPM), the correction for multiple comparisons in extent is based on the Euler characteristic which uses the volume, smoothness, and surface area to calculate the expected extent size, by chance, at any given height threshold.
For example, directly measuring allelic-specific RNA expression in brain tumors revealed a dramatic increase in monoallelic expression of multiple oncogenes, the extent of which correlated with tumor progression and prognosis [ 19].
