In this article, we describe multiple exposure studies using spontaneously hypertensive (SH) and Wistar Kyoto (WKY) rats.
From these multiple exposure studies, four studies included neurological assessment (with or without auditory assessment) in children under 5 years old, and two studies were RCTs.
Seven of eight single-exposure studies conducted a pre-treatment neurological and/or auditory baseline assessment, allowing pre-to-post comparison; however, only two of the multiple exposure studies did so.
Based on the literature to date, it is suggested that hierarchical methods should become part of the standard approaches to multiple-exposure studies.
Finally, we performed sensitivity analyses in which we calculated estimates after excluding offspring with multiple exposures across study periods.
Future studies evaluating these exposures in relation to mammographic breast density or breast cancer risk should seek to use longitudinal study designs, multiple exposure assessments, and diverse study populations.
We identified births during 6/1/04-3/31/06 to women residing within five miles of a Southern California Air Quality Management District (SCAQMD) Multiple Air Toxics Exposure Study (MATES III) monitoring station.
In March 2000, the South Coast Air Quality Management District published results of the second Multiple Air Toxics Exposure Study, indicating an overall average cancer risk in the South Coast Air Basin of about 1,400 per 1 million due to diesel emissions.
In this paper we focused on acute and short-term impacts of pesticides on adult mortality during spring and summer in a one-substance approach (multiple exposure were not studied here) but for a large variety of active substances (a.s).s
Multiple exposure assessment and toxicological studies have been conducted at this location (e.g., Harkema at al. 2009; Keeler et al. 2005; Morishita et al. 2006).
Because our study involves multiple exposure and genetic factors, we explored the gene gene and gene environmental interactions using the logic regression approach (51).
