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This, however, also limited the analyses by creating multiple exposure categories.
When including grouping for multiple exposure categories, the proportion of HIV diagnoses in Australia with injecting as an exposure category increases to almost 8% [ 3].
Another limitation of the study was a narrow exposure gradient for bottled water intake which precluded examination of multiple exposure categories.
We used time varying definitions for drug exposure for all analyses, allowing patients to fluctuate between exposure classifications or contribute time to multiple exposure categories simultaneously depending on prescribing patterns.
Strömberg and Björk [ 17] have considered a similar setting and we now extend their work in two important ways: 1) we allow for a trichotomous exposure (with straightforward generalizations to multiple exposure categories) on the individual level; 2) we allow for collection of data on confounders, together with individual-level exposure data, in the second phase.
In the case of multiple exposure categories, non-differential misclassification may lead to an over-estimation of the risk parameters, especially when it occurs among non-contiguous exposure categories (Dosemeci et al., 1990; Birkett 1992; Wacholder 1995) Jurek et al. (2005) conducted a simulation study that indicated bias towards the null cannot be assumed.
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Statistical imprecision of estimates may be a concern if many variables are necessary to appropriately estimate a given domain or overall environment and a limited number of outcomes are being distributed across multiple exposure and covariate categories.
Consequently, current users, initiators, past users, multiple and non-users represented mutually exclusive exposure categories.
It is likely that multiple metabolites must be measured to accurately classify exposure categories.
As the exposure categories were overlapping, an analysis with multiple logistic regression models comprising both exposure to SAP and paper dust was performed (Table 4).
For individuals who held multiple jobs, we used an average score to assign the exposure categories.
More suggestions(15)
multiple exposure relationships
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multiple exposure windows
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