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The connection between patterns of cell properties and the emerging tissue deformations is studied in multiple experimental systems, but the general principles remain poorly understood.
In fact, depletion of Cby leads to ectopic activation of β-catenin signaling in multiple experimental systems [19], [23].
This finding has held true for multiple experimental systems ranging from simple populations of engineered Escherichia coli [129], to a cell line treated with retinoic acid [130] and even to individual hematopoietic stem cells [10].
To overcome the limitations of any single experimental system, the analytical strategy used here was to identify genes that exert common phenotypic effects across multiple experimental systems.
As with the previously mentioned agents, CK-1213296 was active in multiple experimental systems, increasing the ATPase activity of cardiac myosin specifically without affecting calcium transients.
However, the availability of multiple experimental systems leads to debate concerning which model, if any, is best suited for a particular therapeutic strategy.
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Overexpression of the STK15/BTAK/Aurora A gene located on chromosome 20q13, which encodes a centrosome-associated serine/threonine kinase, has been shown to induce chromosomal instability, leading to aneuploidy and cell transformation in multiple in vitro experimental systems.
Therefore, it would be insightful to use simpler experimental systems where multiple infection is thought to occur in order to explore the model predictions presented here.
For instance, if multiple experimental nodes with different operating systems are hosted on a single test bed machine, the user can apply full virtualization solutions, such as KVM [8], VMware [9], or VirtualBox [10], to create the virtual machines with different guest operating systems.
Bcl-2 and Bcl-XL appear to function in the same apoptotic pathway [ 7], and both confer resistance to multiple chemotherapy agents when tested in experimental systems.
History dependent multiple time scale dynamics appear repeatedly in experimental systems at several levels of organization.
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