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Hostile men have reliably displayed an exaggerated sympathetic stress response across multiple experimental settings, with cardiovascular reactivity for blood pressure and heart rate concurrent with lateralized right frontal lobe stress (Trajanoski et al., in Diabetes Care 19(19961412–1415, 1996; see Heilman et al., in J Neurol Neurosurg Psychiatry 38(19759–72, 1975).
The age-related expression patterns highlighted in this analysis represent systemic or near-systemic effects, which have repeatedly emerged in multiple experimental settings.
To gain a better understanding of the direct role of HIF-1α in human APL, a list of bona fide HIF-1α target genes was constructed based on current literature (Wenger et al, 2005) by selecting HIF-1α targets validated in multiple experimental settings and provided with functional HIF-1α binding sites (Supplementary Table S1).
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Although the involvement of autophagy in cell death has been elucidated in multiple experimental and physiological settings, the role of autophagy in dying cells remains a subject of debate [39], [40].
Model-based design of experiments (MBDoE) techniques can be successfully adopted to design multiple experiments to be executed simultaneously, detecting a proper set of experimental settings improving the identifiability of the model parameters.
As a consequence, an improper handling of multiple gene expression profiles obtained in different experimental settings would capture similarities in these settings rather than in the represented biological states (a phenomenon known as the 'batch effect' [57]).
Multiple factors govern the transmission of prions in experimental settings.
It features flexible experimental settings, quality control, automatic filtering, normalization, multiple testing, and differential analyses on arbitrary genomic regions.
To identify microRNAs (miRNAs) regulated by anti- α4 integrin monoclonal antibody therapy (natalizumab) in the peripheral blood of patients with relapsing-remitting (RR) multiple sclerosis (MS) and to confirm their role in experimental settings in vivo.
Multiple biological activities of APC have been demonstrated both in clinical and experimental settings, comprising pro-fibrinolytic, immune-modulating and anti-apoptotic properties [ 15- 21].
A thorough investigation using multiple experimental methods is prudent before assigning a BCS classification, to avoid misjudgment in various settings, e.g., drug discovery, formulation design, drug development and regulation.
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