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Because there are many different types of proteases that can operate in various cellular contexts, multiple experimental approaches for their degradomic characterization had to be developed.
Multiple experimental approaches have been applied to generate nearly all possible mutations of target enzymes, allowing the identification of desirable variants with improved properties to meet the practical needs.
Model predictions for linking numbers and sizes of LacI-DNA loops can be tested using multiple experimental approaches, which coupled with theory could address whether proteins or DNA provide the observed flexibility of protein-DNA loops.
This increase in glucose uptake observed with Rab4b siRNA treatment could be explained by the presence of more GLUT4 molecules at the plasma membrane, as evidenced by multiple experimental approaches.
In addition to the original screen, we employed multiple experimental approaches, such as luciferase validation studies, FACS analysis, microarray and Cyquant cell proliferation methods to examine the functional relevance of selected NATs.
Perhaps the most important issue in this field is identifying which findings are consistently supported by multiple experimental approaches.
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We propose that the vectors described herein will greatly facilitate functional assignment to predicted and orphan Plasmodium gene models by multiple experimental genetics approaches.
Multiple promising experimental approaches have failed to show a successful therapeutic translation into humans [10].
Multiple promising experimental approaches have failed to show a successful therapeutic translation into humans [ 10].
The absence of TAFs was confirmed by multiple, independent experimental approaches including immunoblotting, qRT-PCR and ChIP.
These submissions capture correlations between the multiple different experimental approaches that have been undertaken as reported in the modENCODE scientific publications, and will inform users of the correlations that have been found (16, 17).
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