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The genetic associations between common variations in OXTR and ASD have been reported in multiple ethnic populations.
Foreseeing multiple ethnic populations entering Islam, the Prophet in his last sermon had already instructed Muslims to shun distinctions between Arabs and non-Arabs.
In addition, for all genes showing significant cis-association across multiple ethnic populations, the direction of allelic effect on expression was always consistent, strongly supporting the hypothesis that the cis-regulation was derived early and still being maintained in current populations.
Clearly, the association of IL-10 SNPs and PCa risk and progression warrant future large-scale investigation throughout multiple ethnic populations.
The initial findings have been replicated in independent studies in multiple ethnic populations and were summarised in a large global meta-analysis [ 5].
Doing this in multiple ethnic populations when possible, adds significant power to our ability to discern causal variants by allowing the comparison of haplotypes across populations.
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To complicate matters even further, many Southeast Asian countries such as Malaysia are ethnic melting pots with multiple different ethnic populations, fragmenting the consumer market even further.
Malaysia is a multiethnic country in South East Asia representing genetic diversity across multiple large ethnic populations of Asian origin (that is, Malays, Chinese and Indians).
Ellinghaus and colleagues used an Immunochip approach to investigate AD, testing 128 830 SNPs in 2425 cases and 5449 controls, with further replication in multiple diverse ethnic populations [ 46].
To date, few studies have assessed dietary effects on adipokine concentrations, and we know of no previous study to assess dietary glycemic index in relation to adipokine profile and insulin resistance in multiple ethnic groups including populations at high risk.
Further testing is required to determine if this modeling approach, using an optimally selected panel of genetic markers, can provide clinically useful prediction and if generic models can be developed for use across multiple ethnic groups or if population-specific models are required.
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