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Previous genetic screens identified multiple essential regulators of border cell migration, including the highly conserved steroid hormone receptor and receptor tyrosine kinase (RTK) signaling pathways (Liu and Montell 1999; Bai et al. 2000; Duchek and Rørth 2001; Duchek et al. 2001; Silver and Montell 2001; McDonald et al. 2003; Mathieu et al. 2007).
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Small G proteins, which are essential regulators of multiple cellular functions, are activated by guanine nucleotide exchange factors (GEFs) that stimulate the exchange of the tightly bound GDP nucleotide by GTP.
These small regulators have important roles in multiple essential biological processes, including cell differentiation and apoptosis [ 4].
α-Granules contain multiple cytokines, mitogens, pro- and anti-inflammatory factors and other bioactive molecules that are essential regulators in the complex microenvironment of the growing thrombus but also contribute to a number of disease processes.
Microtubules are essential regulators of cell polarity, architecture and motility.
Small non-coding RNAs are essential regulators of gene expression at the transcriptional and posttranscriptional levels.
CDKs are valid targets as they function as essential regulators of cell growth and differentiation.
These studies provide a framework for studying crypt morphogenesis and identify essential regulators of niche formation.
Steroid receptor coactivators (SRCs) are essential regulators of nuclear hormone receptor function.
BCL2 family proteins are essential regulators of apoptosis.
Together, the data suggests that miRNAs are essential regulators of early osteogenic differentiation of hMSC.
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