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It carries out multiple essential functions in cellular processes.
Mitochondrial Hsp70 is a highly conserved member of the HSP70 multigene family and plays multiple essential functions in the biogenesis of mitochondria across kingdoms.
The CXCR4 protein has multiple essential functions, including homing of stem cells and metastasis of cancer cells (Miki et al, 2007).
For this reason, an integrative index that can evaluate multiple essential functions, such as f/Vt ratio and the compliance, rate, oxygenation and pressure (CROP) index [ 11] have been introduced in the literature.
To understand how the core Mediator carries out multiple essential functions, it is critical to characterize the modular architecture, and to understand how the modules are organized and how they interact with each other to enable regulation of transcription.
It is involved in multiple essential functions, from its best-known role in the regulation of protein levels to additional, precise roles in endocytosis, cellular signaling, DNA repair or the regulation of gene expression [ 1- 3].
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Kinesins are a superfamily of microtubule-based ATP-powered motors, important for multiple, essential cellular functions.
Mitochondria are highly dynamic and structurally complex organelles that provide multiple essential metabolic functions.
Retinoids, such as vitamin A (retinol), are involved in multiple essential biological functions including fuel metabolism by controlling adipogenesis and energy homeostasis (112– 112).
On these target molecules the effector complexes mediate multiple essential regulatory functions like transcriptional gene silencing (TGS) or post-transcriptional gene silencing (PTGS) or decreasing the translational rate (reviewed by [ 8, 14]).
S100 proteins have multiple and essential functions in many different tissues, mainly in cells of epithelial origin.
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