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Nevertheless, whole-chromosome arm events, a feature characteristic of multiple epithelial tumor types, are only infrequently seen.
Circulating tumor cells (CTCs) in the peripheral blood are a biomarker of poor prognosis in multiple epithelial tumor types [ 6, 7].
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The animals are unique in that they spontaneously develop multiple epithelial tumors such as MnPV-induced papillomas and McPV2-induced condylomas.
This well-studied transcriptional co-activator is a putative tumor suppressor in multiple epithelial tumors and is part of a t(8 22)(p11 q13) translocation in acute myeloid leukemias (AML) [49].
We therefore chose the ApcMin mouse as the tumor model, as these animals develop multiple epithelial tumors predominantly in the small intestine [ 13].
Sea turtles worldwide are affected by fibropapillomatosis, a disease probably caused by one or several viruses and characterized by multiple epithelial tumors.
For renal pelvis cancer, there is a strong tendency to develop multiple transitional epithelial tumors, particularly in the urinary bladder and ureter.
One of the important findings in the thymic epithelial tumor is frequent and multiple genetic aberrations of chromosome 6 that are found in 77.5percentt of them.
We recently reported that the expression of another DDSP factor, WNT16B, a human Wnt family member, arises from tumor-adjacent stroma on chemotherapy but functions as a paracrine molecule in the TME to alter multiple epithelial phenotypes.4 As an interesting point, the DDSP is not hormone dependent, but rather relies on signals delivered by DNA damage or genotoxic stress indeed.
By contrast, epithelial tumor grade (which includes the assessment of keratinization) was not significantly associated with survival (Table 2).
From an epithelial tumor, cancer cells can reach vessels leading to CTCs.
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