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Consequently, multiple epigenetic events may promote differential non-canonical Wnt stimulation between CRC subtypes.
These interactions are especially significant for multiple epigenetic events, such as chromatin assembly, histone and DNA modifications, and higher-order chromosome structures that control viral episome generation and maintenance after viral infection [ 111– 111].
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Multiple genetic and epigenetic events characterize tumor progression and define the identity of the tumors.
Gastric cancer is chronic proliferative disease characterized by multiple genetic and epigenetic events [ 4- 6].
Gastric carcinogenesis is thought to be a multi-step process that involves multiple genetic and epigenetic events.
This adenoma-carcinoma sequence leading to CC is well described, and is characterized by multiple genetic and epigenetic events [ 29].
As in other cancers, multiple genetic and epigenetic events have been implicated in head and neck carcinogenesis 10.
Consistent with emerging models of carcinogenesis, leukemogenesis is an evolutionary process that involves multiple independent genetic and epigenetic events.
These circuit disturbances are variable across individuals with schizophrenia, perhaps reflecting the interaction of multiple different risk genes and epigenetic events.
Alternative to genetic changes, aberrant epigenetic events disrupt multiple genes involved in cell signaling pathways through DNA methylation of promoter CpG islands and/or histone modifications.
It is possible that resistance to artemisinin is unlike these classical mechanisms in vitro but instead results from a complex series of genetic and epigenetic events affecting multiple pathways.
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