Sentence examples for multiple epigenetic alterations from inspiring English sources

Cancer cells are characterized by multiple epigenetic alterations including DNA methylation and histone modification.

In recent years, increasing evidence has shown that multiple epigenetic alterations, as a hallmark of cancers, also contribute critically to cancer initiation and progression with the same influence as genetic abnormalities [11].

Thus, functional perturbations in multiple molecules, caused by multiple genetic and/or epigenetic alterations, affect multiple metabolic and signal transduction pathways and the combinatorial effect ultimately determines cancer cell survival.

Cancer is a complex disease with multiple genetic and epigenetic alterations.

Most human tumors result from the accumulation of multiple genetic and epigenetic alterations in a single cell.

Cancer is characterized by multiple genetic and epigenetic alterations that drive malignant cell proliferation and confer chemoresistance.

It is generally accepted that the progression of HCC is a long-term process with accumulation of multiple genetic and epigenetic alterations, which further lead to the activation of critical oncogenes or inactivation of tumor suppressor genes.

Cancer is one of many diseases that arise from multiple genetic and epigenetic alterations within a cell [2], [46], [47], [48].

Like most epithelial cancers, HNSCC develops through the accumulation of multiple genetic and epigenetic alterations in a multi-step process [11].

Multiple genetic and epigenetic alterations have been described in thyroid cancers in recent decades.

Oral tumorigenesis is a multistep process caused by accumulation of multiple genetic and epigenetic alterations [ 3].