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In addition to its protease activity, the viral nsP2 protein possesses multiple enzymatic functions including RNA helicase, nucleoside triphosphatase (NTPase) and RNA-dependent 5′-triphosphatase activities [ 11– 13].
The re-annotation pipeline consists in a systematic manual process to find and collect information from different sources, enabling the assignment of one or multiple enzymatic functions to a given putative metabolic gene.
This heterogeneous presynaptic distribution of MGL in several neuronal elements of the nociceptive circuitry is consistent with the concept that its multiple enzymatic functions may vary at distinct synaptic localizations.
NS3 has multiple enzymatic functions, serving as a viral serine protease which cleaves the other nonstructural proteins from the viral polyprotein, in association with NS2B; an RNA helicase in association with NS4a; and an NTPase in association with NS5 [ 44– 44].
PI3-K regulates diverse cellular functions such as growth, survival and malignant transformation through its multiple enzymatic functions, namely lipid kinase and protein kinase activities [ 30, 31], and acts either synergistically with the Raf pathway [ 32] or in opposition to it [ 33].
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- RNA replication is processed by the 2 largest nonstructural proteins with multiple enzymatic activities: (1) NS3 functions as a serine protease (with its cofactor NS2B),, an RNA-stimulated nucleoside triphosphatase, an RNA helicase, and an RNA triphosphatase.
Multiple combinations of different enzymatic functions have produced complex metabolic pathways for the synthesis or degradation of structurally diverse compounds.
Stephanie Wisner '16 will present her research, "Dissecting the Functions of the Multiple Enzymatic Activities of SirT2 in Cancer," Feb. 13, which concerns how the protein SirT2 may be employed in anti-cancer therapies.
Given that many 2OG-dependent dioxygenases have been implicated in the regulation of multiple pathways, global effects on gene expression and metabolism are not surprising when their enzymatic functions get perturbed or ablated.
"We had four different gene deletions — four different enzymatic functions," said Ann Donnelly, lead author on the paper.
The electron transport chain comprises multiple enzymatic complexes of which one or all may be compromised in SS.
More suggestions(15)
multiple biological functions
multiple unusual functions
multiple enzymatic steps
multiple enzymatic turnovers
multiple enzymatic mechanisms
multiple enzymatic specificities
multiple enzymatic events
multiple enzymatic processes
multiple enzymatic reactions
multiple enzymatic activities
multiple molecular functions
multiple enzymatic complexes
multiple neutrophil functions
multiple enzymatic pathways
multiple enzymatic systems
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