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Here we found experimentally that several phenotypic states lost resilience to multiple environmental perturbations near a critical transition.
Second, measurements of plasma glucose, lipid and insulin levels are sensitive to multiple environmental perturbations, such as animal husbandry, testing procedures, and environmental conditions.
Interestingly, we found that refactored genomes achieved greater optimality degrees than those of wild-type genomes for both single and multiple environmental perturbations.
Both pathway-level and metabolite-level analyses helped to identify core metabolic responses to multiple perturbations common across both cell types, with three metabolites identified as a conserved core response module, responding to multiple environmental perturbations in each cell type.
Some of the effects of combinations of multiple environmental perturbations on gene expression cannot be predicted from the individual treatments, as has been shown in tobacco (Rizhsky et al., 2002a), Arabidopsis thaliana (Rasmussen et al., 2013) and sorghum (Johnson et al., 2014).
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However, many species originated in the early- to mid-Pleistocene, meaning that they persisted through the environmental perturbations of multiple glacial cycles.
Although the epigenome is vulnerable to environmental perturbations during multiple points in life, it is particularly susceptible during embryogenesis, neonatal development, and adolescence.
Furthermore, in probing for the existence of multiple network attractors, we experimented with random environmental perturbations (i.e. initial states) drawn from a uniform probability distribution.
ROS bursts are common in plants in response to environmental perturbations and are generated utilizing multiple cellular processes [ 60- 65].
Bacterial communities are integral service providers (Gutknecht et al. 2006), thus conservation and rehabilitation of an impacted area require a thorough understanding of how multiple interactive species adapt to face such dramatic environmental perturbations.
The integrated model of the circadian clock circuit and ABA-regulated environmental sensing allowed us to explain multiple experimental observations on the timing and stomatal responses to genetic and environmental perturbations.
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various environmental perturbations
multiple environmental stresses
multiple oncogenic perturbations
multiple environmental stimuli
multiple environmental sources
multiple interacting perturbations
multiple metabolic perturbations
multiple cellular perturbations
multiple environmental benefits
multiple experimental perturbations
multiple simultaneous perturbations
multiple functional perturbations
multiple environmental timeseries
multiple genetic perturbations
multiple environmental issues
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