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Our standard protocol yields multiple endpoints that enable evaluation of state- and use-dependent block, but complicate the analysis and may not be essential for high-volume screening.
Use of a composite endpoint provides efficacy of "nonspecific" benefits and is valuable in testing multiple endpoints that are suitable for combining.
A possible solution to this dilemma is to design proof-of-concept studies to explore whether a therapy demonstrates consistent indications of a possible clinical benefit for multiple endpoints that are relevant to the disease.
COTC trials are centrally managed and designed to include multiple endpoints that define safety, biological and clinical activity of novel treatment agents.
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These data identify multiple noncanonical endpoints that are pivotal for rational design of hedgehog modulators and provide a new therapeutic avenue for obesity and diabetes.
Apple's challenge is to pry open the carriers to transport the video endpoints from mobile devices, and work with Google and others to create software to take advantage of multiple collaborative endpoints that know where you are and behave accordingly.
The aims of the present research thus were to further validate the NTG migraine model in rats by comparing the effects of single versus multiple NTG episodes on behavioral endpoints that reflect ICHD-3 diagnostic symptoms of migraine, including pain intensity, photophobia, and alterations in motor activity.
Method: We examined the main cohort of the SCDS to determine if this might be true using a longitudinal multiple regression analysis design that focused on those endpoints that were repeatedly measured at different ages.
The classical readouts of such image-based high-throughput screenings are fixed endpoints that can gather data from multiple image channels.
Where multiple overlapping rearrangements have occurred between genomes, the two specific endpoints that define a particular inversion may not be determinable.
However, behavioral and physiological endpoints that link the organism and molecular level endpoints are scarce.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com