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Together, this model demonstrates integrated capabilities for assessing multiple endpoints including axon tract tracing, calcium influx, network architecture and activities.
The benefits of etoricoxib were observed consistently across multiple endpoints, including Pain Intensity at Rest, Pain Intensity with Knee Flexion, Total Daily Dose of Morphine consumption, and Opioid Side Effects Scale scores.
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CRT has been shown to improve heart failure-specific quality of life, along with multiple clinical endpoints including heart failure symptoms, exercise capacity, hospitalization rates, and longevity (Abraham 2003; Bradley et al 2003).
There were multiple secondary endpoints including ACR20/50/70 response, DAS28 less than 3.2, DAS28 less than 2.6, simplified disease activity index (SDAI) of 11 or less, SDAI of 3.3 or less, which were also planned for week 78.
There are multiple secondary endpoints including systolic and diastolic blood pressure, random cholesterol, HDL cholesterol, ApoA1 and ApoB apolipoproteins, CVD risk score as assessed by the UKPDS risk engine (version 2) [ 42] and additionally in London only, a measurement of arterial stiffness assessed by pulse wave velocity.
Studies that evaluated multiple endpoints were included in each study endpoint category.
Frequencies for specific risk factors by endpoint are presented in Table 2. Reference numbers for the papers examining each risk factor for each endpoint are provided in Table 3. * Papers that reported on multiple endpoints are included in each of the relevant columns.
Secondary endpoints were safety endpoints, including bleeding risk.
No consistent trends were observed across other endpoints, including the powered secondary endpoint.
Other endpoints, including safety parameters, were summarized using descriptive statistics.
For participants who experienced multiple endpoints, the analysis included only the first event.
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