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Third, multiple endpoint analyses are demonstrated to validate the invasion.
The invasive transition of DCIS in our lumen-based model was validated by multiple endpoint analyses.
Experimentations aimed to identify underlying molecular mechanisms and additional drug-drug interactions using multiple endpoint analyses, revealed in breast cancer cells expressing low levels of Her2, beneficial drug-drug interactions on the basis of endpoints measuring AKT phosphorylation and F-actin cytoarchitecture.
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A hierarchical procedure will be used to control type I error and handle multiple secondary endpoints analyses.
The secondary endpoints are partially redundant with the primary endpoint; therefore, p-values from secondary endpoint analyses are being reported here for exploratory analysis purposes and correction of multiple comparisons were not conducted.
Secondary endpoint analyses were performed using the last observation carried forward, and were not adjusted for multiple comparisons.
HBP was tested on 601 patients, who were all included in the secondary endpoint analyses.
The primary endpoint analysis (n = 511) and the secondary endpoint analyses (n = 601) were performed on available patients, samples and data.
Secondary endpoint analyses are considered as exploratory.
Notably, 4% of randomised participants did not have an endpoint blood pressure recorded and were excluded from endpoint analyses.
Hence, OS analyses will be diluted, calling for endpoint analyses focusing on recurrence of the disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com