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Multiple endogenous signals and environmental cues also interact with the GA-GID1-DELLA regulatory module by affecting the expression of GA metabolism genes, and hence GA content and DELLA levels.
In the context of sterile inflammation such as in the case of RA, multiple endogenous signals have been shown to induce NLRP3-inflammasome expression and activation.
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The transition from the vegetative to reproductive stage of development is controlled by multiple environmental and endogenous signals that ultimately modulate the expression of key gene regulators of floral identity: APETALA1 (AP1)/ CAULIFLOWER (CAL) and LEAFY (LFY) [ 35, 36].
In contrast to caspase-3, which integrates multiple endogenous and extracellular stimuli, caspase-8 is specifically activated within the death receptor-induced signalling complex (DISC).
These overlaps in signalling processes induced by multiple stimuli suggest that two-component proteins are key sensors and transducers of various environmental and endogenous signals.
In contrast to their weak actions via genomic signaling pathways, these compounds are profoundly effective in disrupting nongenomic responses to multiple endogenous estrogens at concentrations that represent different life stages.
Coupling of dCas9 to a transcriptional repressor domain can robustly silence expression of multiple endogenous genes.
Diurnal control is mediated by multiple endogenous and exogenous mechanisms, even at the level of individual genes.
The CRISPR ChaCha is dose-dependent, reversible, and can activate multiple endogenous genes simultaneously in response to extracellular ligands.
It is therefore relatively simple to produce numerous sgRNAs to target multiple endogenous sequences.
The results showed that transitivity could be responsible of multiple endogenous genes knock-down.
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