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To determine whether elective single embryo transfer (eSET) lowers the risk of poor perinatal outcomes associated with IVF, when [1] compared with double embryo transfer (DET) or multiple embryo transfer (MET), and separately, [2] compared with spontaneous conceptions.
Most babies are born healthy from multiple births or (IVF), but there are a number of reasons why single embryo transfers is a better option than multiple embryo transfer," Dolk said.
This should include measures that monitor the impact on perinatal mortality of multiple embryo transfer.
However, there has been a persistent gap between live birth rates from SET and multiple embryo transfer.
We believe that the EU model approach, despite its limitations, is currently the only practical approach that can properly account for the data structure encountered in the analysis of IVF data with multiple embryo transfer.
However, because of extensive evidence in the reduction of twin pregnancy rates to 0-1% with use of single embryo transfer 7 8 9 compared with about 23% with double or multiple embryo transfer, 14 the authors believe this 11% difference to be relevant for clinical practice.
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Insuring fertility medicine would mean regulation, and multiple embryo transfers and their risks would become less common.
Due to the persisting high rates of multiple embryo transfers and of multiple birth internationally best practice is to report all mortality measures by number of embryo transfers (SET, DET and all transfers) and plurality (singletons, twins and all).
As noted by Roberts et al.[ 10] the level at which a covariate acts is identifiable (albeit not strongly) through the twin rate if there are multiple embryos transferred per cycle.
Fishel says such studies will need to distinguish whether these adults are a product of a single- or multiple-embryo transfer, irrespective of whether they were a product of a multiple pregnancy.
The specific criteria, however, are difficult to establish, as evidence is limited due to multiple-embryo transfers either confounding the analysis or lacking in the case of SET, when additional embryos are not used.
More suggestions(15)
multiple file transfer
multiple cargo transfer
multiple gene transfer
multiple saturation transfer
multiple methyl transfer
multiple embryo recognition
multiple knowledge transfer
multiple mass transfer
multiple muscle transfer
multiple source transfer
multiple embryo implantation
multiple coherence transfer
multiple charge transfer
multiple block transfer
multiple layer transfer
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