Exact(11)
We evaluated 50% responder rate for three treatment cycles across multiple efficacy variables.
To accelerate development of these new reperfusion regimens, an integrated approach to phase II clinical trials that incorporates multiple efficacy variables, including angiography and noninvasive biomarkers of microvascular dysfunction, should be considered.
These findings, along with data from the literature [50], suggest that multiple efficacy measures should be considered to fully reflect clinical relevance, not only in regulatory clinical trials but also, and more importantly, in the real-life setting.
Multiple efficacy endpoints were evaluated in this study.
Overall, exploratory comparison showed similar responses to subcutaneous OKZ treatment and intravenously administered TCZ across multiple efficacy endpoints and for several OKZ treatment groups.
A sequential, hierarchical hypothesis testing of the multiple efficacy endpoints was prespecified to maintain control of Type I errors based on multiple hypothesis testing.
Similar(49)
The multiple efficacies of interventions are important to track because they may exhibit distinct temporal scales, with the physical integrity and insecticide concentrations of ITNs a classical example.
Structurally, this previous model differs from ours due to a different and less detailed utilisation of pain states and because it was not able to model the multiple efficacies (direct and indirect) now known of the vaccine.
Single-agent bortezomib in previously untreated multiple myeloma: efficacy, characterization of peripheral neuropathy, and molecular correlations with response and neuropathy.
Rosinol L, Oriol A, Mateos MV, Sureda A, Garcia-Sanchez P, Gutierrez N, et al. Phase II PETHEMA trial of alternating bortezomib and dexamethasone as induction regimen before autologous stem-cell transplantation in younger patients with multiple myeloma: efficacy and clinical implications of tumor response kinetics.
This explains in part the multiple target efficacy exerted by plant-based products.
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