Promoter methylation of insulin-like growth factor is affected by alcohol (Zhou et al. 2011), which is known as a highly psychoactive drug appreciated both by artists and art consumers and provides an example for multiple epigenetic effects resulting from its (over consumption (Meeran et al. 2010; Shukla et al. 2008).
Therefore, it is highly desirable to develop a new empirical approach to effectively remove the spatially inhomogeneous echo-shifting effects resulting from multiple sources.
Thus, the postseismic surface deformation (produced by a combination of effects resulting from multiple subsurface deformation mechanisms) of a larger earthquake may have a broader spectrum of timescales, and more decay function terms with different timescales may therefore be required to fit the time series of the postseismic deformation.
In the groundbreaking Adverse Childhood Experiences (ACE) studies, researchers suggest that the amplified health effects resulting from multiple adverse experiences in childhood, including violence, are due to the exposure of the brain to the stress response, which impairs brain structure and function [ 88, 89].
On the other hand, as shown in Table 7, the multiple-conformer effect resulted in more bioassays that had NN-pair CT and ComboT score averages equal to or greater than the respective μ + 2σ thresholds.
Key findings were that the expression of a happy versus nervous emotion at the end of a problem-solving sequence had multiple effects: happy emotions resulted in higher leadership ratings, higher trait ratings, greater correlations among trait ratings, and greater dependence of trait ratings on leadership perceptions.
In this simplified framework, the synergistic effect resulting from multiple perturbations of the metabolic network is still well captured [ 7, 22] (see Figure 1 for a simple example).
Yet the findings of in vitro studies [ 16] and experimental studies on rats [ 17- 19] show that TCDD, the most toxic compound in the DLC family, has multiple effects on bone tissue, resulting in increased bone fragility.
However, the mechanism of action remains uncertain and seems to be versatile, resulting in multiple effects, such as anti-inflammatory action.
