Nevertheless, R-flurbiprofen likely combines multiple effects at molecular targets independently of prostaglandins, which are currently being evaluated as therapeutic targets in MS, such as the PPARs (Dunn et al, 2010; Lovett-Racke et al, 2004; Xu & Drew, 2007), NF-κB (Mc Guire et al, 2013; van Loo et al, 2006) and p38 MAPK (Kleinewietfeld et al, 2013).
Cardiovascular markers such as copeptin (proAVP), proET1 or MR-proANP, or adrenomedullin (MR-proADM) which has multiple effects, reflect at least in part non-pulmonary comorbidities [ 19, 20].
Indeed, dopamine's multiple effects (even at low doses) make it the perfect pressor/inotropic agent when such a combination is warranted.
A given gene can exert multiple effects on phenotype at different points in the life history.
Levosimendan is known to exert multiple effects on perfused hearts at concentrations as low as 0.3 μM; the effect of levosimendan on skinned muscle fibers was half-maximal by 0.3 μM and maximal by 10 μM (36), and similar levels of levosimendan modulated contractility in cardiomyocytes (37).
Particularly important is that energy production techniques can have multiple effects on biodiversity, which "operate at different spatial and temporal scales.
If multiple effects are to be emulated at the same time it is necessary to provide one pattern for each type of emulation effect, that is, packet loss, bit-errors insertion, bandwidth change, and delay change.
Moreover, many energy production techniques actually have multiple effects on biodiversity, which operate at different spatial and temporal scales.
A literature review revealed that many energy production techniques actually have multiple effects on biodiversity, which operate at different spatial and temporal scales.
Some of the results of these studies have been difficult to interpret, perhaps because of multiple effects of the same cytokine at different stages of disease.
The increased release of stress hormones results in multiple effects (metabolic, cardiovascular and immune) aimed at restoring homeostasis during stress.
