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The ease with which the LACE system can be redesigned allows for use in difficult systems, such as those where multiple effector regions in a promoter need to be targeted.
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Recent work has revealed that multiple effector genes reside in regions of the wilt genome that undergo regular chromosomal reshuffling.
These deletion studies implicate multiple non-overlapping regions in the ICD that differentially affect growth, PCP and organ shape, suggesting that Ft signals via multiple effector pathways.
Fourth, multiple effector functions were important for tumor resolution: IFN-γ and TRAIL.
So the lymphocyte populations provide multiple effector mechanisms capable of eliminating the R. equi infection.
The efficacy of these responses relies on multiple effector functions such as the secretion of antimicrobial molecules and the direct killing of infected cells by effector lymphocytes [1].
Ultimately the incorporation of multiple effector genes, expressed into combinations of midgut, haemocoel and salivary glands will become feasible.
TG2 expression endows aggressiveness and invasiveness to cancer cells through multiple effector pathways [ 35].
These transformed epithelial cells eventually acquire the multiple effector mechanisms of metastasis [ 17].
Bacterial pathogens deliver multiple effector proteins into eukaryotic cells to subvert host cellular processes and an emerging theme is the cooperation between different effectors.
It has also been shown that the anticancer response of the SR/CR mice involves multiple effector mechanisms [ 3].
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