Sentence examples for multiple effector pathways from inspiring English sources
Our results suggest that a complex cytokine response, involving type 2 as well as type 1 cytokines, is responsible for the ability of Lm-NP-immunized mice to resist tumor challenge, potentially mediating tumor cell killing through multiple effector pathways.
TG2 expression endows aggressiveness and invasiveness to cancer cells through multiple effector pathways [ 35].
Activated Ras becomes engaged with metabolic pathways through multiple effector pathways, including those of PI3K/Akt and MAPK.
Animal studies indicate that immune responses to helminths involve multiple effector pathways directed against different stages of the helminth life cycle [ 5].
These deletion studies implicate multiple non-overlapping regions in the ICD that differentially affect growth, PCP and organ shape, suggesting that Ft signals via multiple effector pathways.
Immunopathological studies indicate that multiple effector pathways can contribute to lesion formation, the relative importance of which may vary between patients or during the course of the disease (Lucchinetti et al., 2000; Prineas et al., 2001).
The T58A c-myc mutant was chosen as a candidate immortalizing agent in considering that the intracellular levels of c-myc protein play a critical role in proliferation and that the stability and accumulation of c-myc are regulated by multiple Ras effector pathways.
Mutant KRAS activates multiple downstream effector pathways, resulting in the uncontrolled growth, proliferation, and survival of cancer cells (Fig. 1).
The existence of multiple downstream effector pathways that converge on common biological outcomes suggests that these pathways might function redundantly to some extent and thus provide robustness.
In normal cells, Ras proteins are only transiently activated, which then act on multiple downstream effector pathways to regulate cell proliferation, survival, and differentiation.
The answer to this question is presently unclear, and it is very likely that multiple TORC1 effector pathways contribute (Blagosklonny and Hall 2009).
