Sentence examples for multiple dysfunctions including from inspiring English sources

Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by hyperglycemia due to multiple dysfunctions including inadequate insulin secretion, resistance to insulin action, and excessive and inappropriate glucagon secretion.

Endotoxin causes multiple organ dysfunctions, including acute lung injury (ALI).

In this review, we highlight the most recent developments in lipid-based therapies to modulate ocular surface inflammation as well as the potential for lipid-based molecules as a biomarker of disease in multiple ocular dysfunctions including DED, diabetic retinopathy, and Fuchs' endothelial corneal dystrophy (FECD) (Table 1).

Protease-cleaved BID is able to induce multiple mitochondrial dysfunctions, including the release of the inter-membrane space proteins, cristae reorganization, depolarization, permeability transition and generation of reactive oxygen species.

The presence of mHtt leads to multiple cellular dysfunctions, including alterations in intracellular signaling pathways, defects in cellular trafficking, transcription deregulation, abnormal synaptic transmission, proteasomal dysfunction and mitochondrial alterations.

This duality is found in human pathology: Iron deficiency (because of poor iron intake, abnormal blood losses etc...) presents with anemia and fatigue; whereas iron overload (mainly in hereditary hemochromatosis and following repeated blood transfusions) induces multiple organ dysfunctions (including liver fibrosis, cirrhosis, cardiomyopathy, diabetes...)...

A hallmark of this disease is (multiple) organ dysfunction, including liver dysfunction, ultimately determining the outcome of sepsis.

Pro- and antiinflammatory cytokines are known to be involved in the pathogenesis of septic shock and multiple organ dysfunction, including liver failure.

Fifteen hours after sepsis induction, animals displayed clinical and laboratory signs of multiple organ dysfunction, including moderate liver injury, cholestasis and an impairment of sinusoidal perfusion.

Exposure of blood to the foreign surface area of the bypass circuit is known to be associated with a complex 'whole body inflammatory reaction', which may contribute to the development of multiple organ dysfunction, including postoperative lung injury.

Taken together, we argue that hypoglycaemia might be a marker of frailty and multiple organ dysfunction including cancer which should alert clinicians to reassess the clinical status and screen for silent conditions such as CKD and occult cancer.