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Clades of five Equisetum diffusum sequences are present in both Groups IV and III genes, indicating multiple duplications affecting GSK3 loci in this species.
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The imbalance of gene family trees suggests that relatively few gene duplications have occurred as segmental duplications affecting multiple loci.
Because the probability of multiple duplication events affecting a single gene increases, the pairwise estimate of the duplication rate becomes increasingly inaccurate beyond dS = 0.3.
Numbers mark duplications affecting whole branches, while homologs in single species, which underwent additional duplications, are described by lowercase letters.
Intriguingly, the available data suggest that this Sp gene cluster has been ancestrally linked to the Hox gene cluster and in the vertebrates appears to have been affected by the multiple duplications of this cluster.
The modularization of type I PKSs almost unexceptionally started with multiple duplications of a single ancestor module.
In addition, the glial cell line-derived neurotrophic factor family has expanded in BMR because of multiple duplications of the gene Gfra1.
Like in mice, the cluster formed by multiple duplications.
Our analyses also indicate that there have been multiple duplications of genes encoding the β-subunit and few (if any) duplications of α-subunit encoding genes.
This suggests that multiple duplications have occurred during vertebrate evolution.
Not only whole gene amplification but also certain partial gene duplications (multiple duplications) can increase the dosage of miRNAs.
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