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But we know that the numbers are rising, because strains of TB that are resistant to multiple drugs — the precursors to XDR-TB — are proliferating.
Drugmakers agreed to cuts of up to 90percenttoto help in the fight against TB strains resistant to multiple drugs, the charity said.
For treatment with multiple drugs, the probability of treatment failure as a result of resistance depends on the quiescence parameters (Figure 4b d).
In the presence of multiple drugs, the susceptible cells are killed at the rate given by the maximum drug-induced rate in the combination.
Because the patient has received multiple drugs, the origin of these adverse events cannot be traced.
Although ABC transporters have been implicated in cellular resistance to multiple drugs, the clinical relevance of these efflux pumps is still poorly understood.
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For example, we assumed less than a fully multiplicative model when considering multiple drugs in the same patient, and variation in our assumptions resulted in similar conclusions.
However, the use of multiple drugs poses the problem of fine-tuning dosing and timing of the interval between injections.
The design of drug delivery systems that can deliver multiple drugs to the posterior segment of the eye is a challenging task in retinal disease treatments.
Polypharmacy, the use of multiple drugs by the same individual [ 1, 2], is increasingly common in older people in both the United States (US) [ 3] and United Kingdom (UK) [ 4].
In case of multiple drugs with the same active substances, we included the ADRs from all the SPCs, thereby eliminating product differences.
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