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Overuse of antibiotics in humans and livestock has led to the rapid evolution of bacteria that are resistant to multiple drugs such that even vancomycin, the drug of last resort, is no longer effective against some strains.
In other diseases treated with multiple drugs, such as tuberculosis, patients can reduce the number of pills once the pathogen appears to be under control.
The results also suggest that the observed association of higher MQ IC50 and pfmdr1 CN in field parasites may be a combined result from selection of multiple drugs such CQ, QN, and MQ.
This suggests that there is no common underlying cause of drug-resistance to multiple drugs, such as broad-specificity drug efflux pump getting over-expressed, or a mutation in a gene that changes the permeability of the mycobacterial cell wall [26].
The PTGS2 (prostaglandin-endoperoxide synthase 2) is the target of multiple drugs such as lenalidomide, pomalidomide and thalidomide.
In addition, multiple drugs, such as quercetin, gemcitabine, actinomycin D, and histone deacetylase inhibitor entinostat, potentiates cancer cell to ABT-737-induced apoptosis by targeting Mcl-1.
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The relative importance of Enterococcus as a pathogen has increased with the occurrence of high-level resistance to multiple antimicrobial drugs, such as ampicillin and vancomycin [ 7].
The relative importance of E. faecium as a pathogen has increased with the occurrence of high-level resistance to multiple antimicrobial drugs, such as ampicillin and vancomycin (4).
These POx micelles not only allow unprecedented high incorporation of nearly 50 wt % PTX but also achieve high loading capacities for multiple other drugs such as 17-AAG, etoposide, and bortezomib and their combinations of up to three agents simultaneously.
And it is clever at finding multiple uses for existing drugs, such as Avastin.
The North American Menopause Society's Menopause Guidebook points out that infection of the bladder (cystitis), other medical conditions such as multiple sclerosis, certain prescription drugs such as diuretics and some tranquilizers, and smoking and eating spicy foods or artificial sweeteners, or drinking alcohol and caffeine can irritate the bladder and worsen incontinence.
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