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Timed sequential release of multiple drugs has also been demonstrated.
In the area of conventional cytotoxic chemotherapy, only the combination of multiple drugs has enabled actual cures for leukemia and lymphoma patients [14].
In recent decades, however, the rates of primary rifampin resistance have increased (Table), and primary resistance to multiple drugs has increased to 2.4% over time.
Taken together, data obtained from the Taiwan Surveillance of Drug Resistance in Tuberculosis and those reported previously show that rates of combined resistance to any drugs and multiple drugs has declined in Taiwan.
For simplicity, we have assumed independence of the effect of the drugs (this has been demonstrated at least for ACE-I [ 3] and aspirin [ 4]), and have examined their impact individually, although an alternative method of handling cumulative risk reduction with the use of multiple drugs has been described [ 5] and could be applied.
The latest data on hospital emergency visits estimates that more than half of the visits related to "drug misuse or abuse" involved more than one drug [ 23] and recent studies reported that simultaneous use of multiple drugs has been shown to contribute substantially to overdose mortality [ 24, 25].
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People who took smaller doses of multiple drugs had fewer side effects than those taking a single drug at the full dose.
Multiple drugs have been designed to prevent or cure osteoporosis.
Multiple drugs have been suggested to stimulate or worsen pancreatitis 31.
Since then, antibiotics—and in some cases, the genes for resistance to multiple drugs—have been found on industrial cattle, swine, and shrimp farms, 5, 6, 7, 8 measured on chicken skins in grocery stores, 9 and even detected in apple orchards sprayed with drugs originally intended for human use.
Dementia, osteoarthritis and fractures/osteoporosis are more prevalent in women than in men, and multiple drugs had been prescribed for these diseases (medians of 6.0, 7.0 and 7.0 medications, respectively; data not shown), which potentially lead to a higher incidence of PIM-induced ADEs.
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