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In some cases, typically where a number of substances were present in nonlethal levels, the pathologist concluded the cause of death was multiple drug toxicity without specifying which specific substances were responsible.
There was a non-significant trend of higher likelihood of lethal levels of opioids among BD decedents (excluding n = 21 with unknown multiple drug toxicity) who had comorbid substance abuse compared to no such comorbidity (47.1 vs. 22.9%; χ 2 = 3.15, df = 1, p = .076).076
The cause of death was subsequently ruled accidental as a result of multiple drug toxicity.
One patient died in the lubiprostone-treated group of a cause unrelated to treatment (accidental multiple drug toxicity; taking diazepam and two different formulations of hydrocodone plus acetaminophen).
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Disappointingly few drugs are available in clinical practice Pentamidine, Antimonials, Amphotericin B and Miltefosine— and efficacy is limited due to the toxicity and increasing multiple drug resistance [8] [10].
Co-culturing of hepatocytes and nonhepatic primary cells from other organs in the integrated discrete multiple organ co-culture (IdMOC) may allow the evaluation of multiple organ interactions in drug metabolism and drug toxicity.
Combination of these two drugs has recently emerged as a promising combination strategy to improve the patient outcome and drug toxicity, especially in the treatment of multiple myeloma (MM) and hematologic cancers [ 44].
The renal diseases identified were from multiple causes including direct HIV-induced renal damage, HAART drug toxicity, but also commonly non-HIV, non-antiretroviral related comorbidities, notably diabetes and hypertension.
In particular, the potential interrupting multiple kinase networks has for increasing the likelihood of adverse effects and drug toxicity is likely to be an important factor in determining the optimal use of these agents.
The dramatic consequences of antineoplastic medication errors are crucial given the nature of anticancer drug toxicity, the use of antineoplastics drugs in complex multiple-drug regimens, and the overall health status of cancer patients.
Here, we use the well-studied multiple antibiotic resistance (MAR) system in E. coli to experimentally characterize the trade-off between drug toxicity ("cost") and drug-induced resistance ("benefit") mediated by efflux pumps.
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