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Resistance to rifampicin is widely considered a surrogate marker for multiple drug resistant TB.
Parkhill, J. et al. Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18.
Multiple Drug Resistant (MDR) bacteria are no more inhibited by the front line antibiotics due to extreme resistance.
In this study, plasmids (>23 kb to 2.9 kb) were detected in 70.3% strains, and 54.9% plasmid bearing strains were multiple drug resistant (MDR).
Several analogs exhibited single digit μM activity against drug resistant bacteria including; multiple drug resistant Mycobacterium tuberculosis, extremely drug resistant Mycobacterium tuberculosis and MRSA.
The most potent compound (11) in antibacterial assay shows MIC50 of 0.11 μg/mL against Multiple drug resistant Escherichia coli, being about 51-fold more potent than ciprofloxacin.
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It has been shown that multiple drug-resistant mutations and disparate mechanisms of resistance can frequently occur in a single population of tumor cells [ 30, 36- 38].
Antibiotic resistance is a growing problem in multiple drug-resistant tuberculosis (MDR-TB) infections.
Using whole-exome sequencing and functional analyses, we have investigated the nature and pleiotropy of vemurafenib resistance in a melanoma patient carrying multiple drug-resistant metastases.
To assess the effectiveness of a fourth-generation fluoroquinolone for prophylaxis against multiple drug-resistant staphylococcal keratitis after lamellar keratectomy in a rabbit model.
Many multiple drug-resistant mycobacteria have emerged, and their incidents are constantly increasing [3].
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