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These dendrimers take advantage of a dendritic display to carry multiple drug molecules and targeting moieties simultaneously.
Micelles containing multiple drug molecules were an efficient means to increase loading and intracellular delivery of low-potency curcumin [ 19].
Because each GO sheet can carry multiple drug molecules into the film, a larger total amount of DEX can be loaded as a result of increased sonication treatment.
In fact, the combinatorial use of different, but multiple drug molecules that bind to different noncompetitive sites of the same target, may actually provide an additional mechanism to control a target more selectively.
Similar(56)
This new class of molecules is designed to undergo a cascade of intramolecular reactions in response to the cleavage of a trigger moiety, resulting in molecular fragmentation and the release of multiple reporter or drug molecules.
For example, an apparent potency can be augmented by the use of multiple but selective drug molecules, provided they bind to different sites.
Such drug molecules simultaneously target multiple etiologies that have been found to be important modulators in specific diseases.
Thus, we present a robust tool that can be used for multiple applications, including the discovery of new drug molecules.
Hybrid drugs featuring two or more potentially bioactive pharmacophores have been recognized as advanced and superior chemical entities to simultaneously modulate multiple drug targets of multifactorial diseases, thus overcoming the severe side effects associated with a single drug molecule.
This reinforces the belief that drug molecules, at least partly, work by interfering with the function of multiple targets within the cellular milieu.
For example, the control of drug accessibility to tumor cells by increasing the efflux of the drug molecules (multidrug resistance) is a major factor in the failure of multiple forms of chemotherapy [22].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com