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While the association of alcohol and fatal car crashes has long been recognized, the legalization of marijuana for both medical and recreational use and the presence of multiple drug combinations could pose increased threats to motor vehicle occupant safety (Anderson and Rees 2014; Johnson et al. 2012).
These observations suggest that multiple drug combinations may be required to overcome resistance.
Analyses will consider actual treatment patterns in more detail and explore multiple drug combinations.
The longer TTP and OS of multiple drug combinations may be due to more strict inclusion criteria of potentially more toxic regimens and may indicate selection bias.
For the fact that we can only directly obtain the gene expression data of single drugs, we should first represent the feature of pairwise (or multiple) drug combinations.
Not only can the inhibitory effect of different plants in combinations of more than two be determined; new multiple drug combinations can be screened too.
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Importantly, a multiple drug combination should not be discarded as a result of its low combinability because of synergy in toxicity alone, as this synergistic interaction may also occur at tumour cell level.
Multiple drug combination is a promising strategy in biomedical fields, such as cancer chemotherapy and tissue engineering.
Based on these results, multiple drug combination in bortezomib retreatment is considered an effective and relatively safe method, even if patients were previously exposed to bortezomib.
The present review does not intend to negate the important role of diuretics in certain groups of patients (blacks, salt-sensitive patients, concomitant heart failure) or to underestimate their role in multiple-drug combinations in patients with resistant hypertension.
However, the tolerability of multiple successive chemotherapy regimens should compare favorably with multiple-drugs combinations [ 5].
More suggestions(15)
multiple drug drug combinations
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