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The types of overused medication by MOH + CM patients included simple analgesics (3/44), triptan (1/44), opioids (1/44), combination analgesics (33/44), and multiple drug classes (6/44).
Additionally, recent quantitative trait locus analysis and computational mapping have identified Kcnj9 (mouse Girk3) as a candidate gene affecting variability in the analgesia induced by multiple drug classes [4].
Two cytotoxic trials studied agents belonging to multiple drug classes [ 75, 88].
Especially in the metastatic setting, where expected survival time may be very short, the use of drug combinations or sequential use of multiple drug classes is commonplace.
It has been well documented that carbapenemase-bearing plasmids frequently carry determinants of resistance to multiple drug classes (1, 6, 9 ).
Most alarming is the evolution of extended-spectrum β-lactamase producing Enterobacteriaceae, as well as multidrug resistant Pseudomonas aeruginosa (PA), some resistant to multiple drug classes [ 4, 5].
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In the EuroSida study, six years after treatment initiation, up to 20% of the patients experienced multiple drug class failure which was associated with poorer clinical status [15].
Multiple drug class combinations are often prescribed for the treatment of schizophrenia, although antipsychotic monotherapy reflects FDA labeling and scientific justification for combinations is highly variable.
All isolates tested demonstrated resistance to multiple antimicrobial drug classes (Table).
Mutations conferring resistance to multiple antiretroviral drug classes may also predominate in compartments where drug levels are suboptimal.
Most resistant isolates now demonstrate reduced susceptibility to multiple antimicrobial drug classes, including β-lactams, macrolides, and tetracyclines.
More suggestions(15)
multiple data classes
multiple drug allergies
multiple protein classes
multiple drug tests
multiple user classes
multiple drug overdoses
multiple traffic classes
multiple drug treatments
multiple drug prescriptions
multiple insecticide classes
multiple dance classes
multiple asset classes
multiple novel classes
multiple drug combinations
multiple drug targets
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CEO of Professional Science Editing for Scientists @ prosciediting.com