Sentence examples for multiple doses with from inspiring English sources

They suggested the use of multiple doses with an appropriate injection volume would achieve maximum therapeutic effects [62].

Individual Cmax and AUC24 values of abiraterone after multiple doses with and without prednisolone were not largely different.

In this review we include community trials that measure effects after a single dose of deworming drugs ('efficacy' measures in the individual), as well as trials of multiple doses with longer follow-up periods.

10– 12 In Phase I clinical studies in healthy subjects, oritavancin exhibited similar pharmacokinetics whether given in single or multiple doses, with very little drug accumulation over a 24-hour period.

Pharmacokinetic data indicated plasma accumulation of tivantinib after multiple doses, with an area under the plasma concentration-time curve among HCC patients approximately two-fold higher than in patients with other solid tumours, but there was high interpatient variability.

The incidence of surgical site infection was estimated to be 2.5% for single-dose prophylaxis and 2.0% for multiple doses, with no statistically significant difference between the 2 prophylactic regimes (risk ratio: 1.24; 95% CI: 0.60 2.60).

The bFGF and IL-8 plasma levels showed no relevant changes after 14 days of multiple dosing with telatinib.

The increase in AUC observed with escalating doses of rIL-21 following single and multiple dosing with 30 and 100  μg kg−1 rIL-21 was linear in nature.

The geometric means for AUC (0 12) and Cmax calculated were within the range of values observed after multiple dosing with 400 mg per b.i.d.

The PBPK model was also able to recover the steady-state plasma levels after multiple dosing with and without the coadministration of KETO.

On average, concomitant administration of single oral doses of 1 mg or 2 mg of sirolimus did not influence AUC(0−12 h) (P=0.67) and Cmax (P=0.96) of sorafenib following multiple dosing with 200 mg b.i.d. of sorafenib.