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Therefore, when an influenza virus strain is completely novel - as in the H5N1 virus - multiple doses (that is, two or more doses) of vaccine may be necessary to achieve protection.
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The trials could not be included because they used different pain measures, over relatively short periods, or had multiple dosing regimens that obscured the efficacy of the first dose.
But efficacy, tolerability, and safety need to be tested in more trials and more patients, perhaps especially in multiple dose studies that capture more information than a single dose efficacy study can do.
Interestingly, these compounds have lethal doses that are multiple-times (at least 100-fold) above their antiviral concentrations [48].
We further confirmed in separate experiments, and at multiple doses of virus, that the ΔA51R virus displays attenuated virulence compared to VACV-WR.
We also sorted the forest plot for weight (in all children in an endemic area after multiple doses) by year that the trial was carried out to visually inspect whether the intervention effect changed over time.
A dosing gun or pistol syringe similarly has a glass barrel (typically loaded with multiple doses) with a plunger that has a thick rubber washer at the end to form a vacuum, a needle and a handle-trigger that is the same as that on a caulking gun.
The output of these simulations as a function of stimulus duration shows multiple dose-response curves that do not coincide, indicating that duration is not the only predictor of switching probability or fraction of active cells.
Results from the different immunisation schedules that have been used in Canada revealed that multiple doses in early infancy provides little additional benefit over programmes starting with 1 dose at the age of 12 months [ 19].
Vaccines that require multiple doses to be effective may be delivered via a smart particle that can achieve the same result.
Although logistically difficult, clinics can also arrange times for multiple travelers to be seen simultaneously for YF vaccination; this strategy takes advantage of multiple-dose vials that might be more readily available.
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