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"You certainly don't want to give yourself multiple doses in a short period of time".
To determine the duration of action of ketotifen 0.025% eye drops vs placebo taken as single or multiple doses in an allergen challenge model.
In Colorado and Washington State, there is a 10 mg THC limit per dose (e.g. one gummy), but it is legal to have multiple doses in one package.
Rivaroxaban was well tolerated and had predictable pharmacokinetics at different single and multiple doses in healthy volunteers [ 11, 12, 16].
While a study used a flexible dose with titration, the others applied fixed and multiple doses in several arms.
Conversely, the potential of high-potency sweeteners themselves to bioaccumulate after single or multiple doses in the presence of coadministered drugs also requires further study.
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Vaccination experiments and multiple dosing in primates were used to further define the activity and safety profiles of MDX-010.
Moreover, there have been reports of the glucuronidation of paracetamol being up-regulated upon multiple dosing in adults [ 6] as well as in neonates and infants [ 7, 8].
XEN-D0501 was rapidly absorbed wash tmax occurapidlyithin 0.5 to 4 h following single absorbediple dosing in part 1 (Table 1, Figure 1).
The multiple ascending-dose study was conducted to identify the drug's pharmacokinetic behavior and the maximum tolerated multiple dose, in order to confirm or adjust the pharmacokinetic sampling schedule that was based on the previous single ascending-dose results.
An effect on average weight was seen in one cluster-RCT assessing long-term multiple dosing in a low-burden community undertaken in 1995 in India (Awasthi 1995 (Cluster)).
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