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Therefore, we next investigated multiple doses at or below 25μM resveratrol for both rat and human ADSCs.
No significant changes in renal clearance were observed after multiple doses at all dose levels.
DTP vaccine is recommended as multiple doses at 2, 3 and 4 months and a booster at 16 months.
Further studies on a large number of appropriate subjects using single dose as well as multiple doses at various stages of pregnancy are warranted.
The patients may have taken multiple doses at the same time, or patients may have actuated their inhaler but not taken the medication.
Based on the pharmacokinetic concentration profile of olaratumab, the trough concentrations following single and multiple doses at 15 mg/kg on days 1 and 8 every 3 weeks (cohort 3) and multiple doses at 20 mg/kg every 2 weeks (cohort 2) were above the 155 μg/mL target.
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BMS-911543 did not accumulate in plasma after two-week multiple dosing at doses of 5, 10, and 20 mg.
In the present study, we have explored clinically relevant multiple dosing at weekly intervals, 2, 3, or 4 times.
Consistent with the accumulation observed after multiple dosing (≥40 mg), the values of Cmax and AUC increased in a greater than dose proportional manner after multiple dosing at doses higher than 40 mg.
A dose-proportional increase in the area under the plasma concentration-time curve over the dosing interval (AUC0−tau) was suggested for TAK-285 after multiple dosing at doses ranging from 50 to 300 mg b.i.d.
40 Although a maximum tolerated single dose was not established, multiple dosing at 10 mg/kg resulted in better objective responses and durable stable diseases than was observed in the single high dose group.
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