Sentence examples for multiple doses as from inspiring English sources
Possibly due to the longer half-life, single dosing was efficacious; not excluding that improved efficacy might be obtained with multiple doses, as has been shown clinically with a more short-lived alpha emitter [9].
After 5 days of infection with TB40-E, CD34+ cells were treated or not (mock) with chloroquine in single or multiple doses as indicated.
However, the 118A>G polymorphism in the human μ-opioid receptor gene also affects response to treatment after multiple doses as well, because cancer patients homozygous for the 118G allele need higher morphine doses to achieve pain control [ 13].
Lebrikizumab serum concentrations accumulated with multiple doses, as shown by an almost twofold increase in the predose trough concentrations between Week 4 (Day 28) and Week 12 (Day 84) (Supporting information Fig. S2).
We carried out a community based, three arm, blinded, randomised controlled trial to investigate the relative clinical effectiveness of multiple doses (as used for most episodes of fever) of paracetamol plus ibuprofen compared with either drug alone.
Primary prostate epithelial cell cultures were irradiated with single or multiple doses, as indicated in the Figure, and incubated for 48 h before staining for β‐galactosidase (pH 6.0) to measure senescence.
Further studies on a large number of appropriate subjects using single dose as well as multiple doses at various stages of pregnancy are warranted.
DTP vaccine is recommended as multiple doses at 2, 3 and 4 months and a booster at 16 months.
We compared the efficacy of EZN-2208 and CPT-11, as single or multiple doses at their respective MTDs, to inhibit HIF-1-dependent luciferase expression and tumor growth in U251-HRE xenografts.
Furthermore, both the inactivated Japanese encephalitis vaccine and the tick-borne encephalitis vaccine, which are also flaviviruses but transmitted via non-Aedes vectors, do not produce long-lasting immunity despite multiple dosing as regular boosters are recommended by the WHO52,53.
Such studies are becoming more and more common, EMA writes; for instance, the trial in Rennes included subtrials using single and multiple dose administration, as well as trials on drug interactions with food and on pharmacodynamics, the study of a drug's biochemical and physiologic effects on the body.
