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Although, majority of patients find the multiple dose regimes cumbersome, they are skeptical about the use of the fixed dose combination treatment regime.
Therefore 500 pregnant women were randomly allocated into two arms; 250 received a single dose regime and 250 received multiple dose regimes.
This trial did not involve new drugs but only determined the efficacy of a single dose regime versus multiple dose regimes; however GCP and Declaration of Helsinki were observed.
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Whereas, 60.9% (1023/1681) find the present dose regime cumbersome, 39.1% (657/1681) of the patients prefer the multiple dose regime.
Multiple doses regime is associated with higher medication cost than single dose regime.
The altered pharmacokinetics and tissue distribution profiles of both liposomal ZD6126 formulations resulted both in single-dose and multiple-dose regimes, in improved therapeutic efficacy in established murine B16.F10 melanomas compared with free ZD6126.
Antibiotic prophylaxis is based on intravenous administration of 1 g cefazolin, with the multiple-dose regime consisting of 4 perioperative doses.
All of the patients were being treated with a multiple-dose regime, consisting of rapid- or short-acting insulin before meals and intermediate-acting insulin once or twice daily.
multiple dose activated charcoal.
Different dose regimes have been used in previous studies.
RIPC: Remote Ischemic Preconditioning, SD: Single Dose, MD: Multiple Dose.
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