Sentence examples for multiple dose regimens from inspiring English sources
Although the studies were preliminary in nature, we have shown that this MNT as well as another MNT incorporating the same DTox-HMP-NLS modules but with α-melanocyte-stimulating hormone as the ligand module were not toxic to mice when administered either as a single injection at the maximum achievable dose or when administered in multiple dose regimens [6].
The immune responses following a single injection in the current study (which was performed before the results of the Step study became available) appear to compare favorably with responses in studies of multiple dose regimens of adenovectors alone or in combination with DNA plasmids, but there are some differences.
We found possible dose dependent effects in multiple dose regimens but not in single dose regimens.
In multiple dose regimens steroids are usually administered at least 12 hours before extubation and repeated almost every plasma half life.
Intention-to-treat analysis was used to determine the equivalence between a single dose and multiple dose regimens; we set the equivalence margin at 5%.
The results presented in the paper clearly indicated that the novel C-seco derivative IDN 5390, was well tolerated in protracted multiple dose regimens.
This fact made the evaluation of a multiple dose regimen protocol surgically impracticable.
We also found a possible dose-effect relation between steroid dose and its effect on preventing laryngeal oedema after extubation and reintubation in the multiple dose regimen.
In the multiple dose regimen, however, the effect of steroids equivalent to 160 mg methylprednisolone (0.18, 0.34) was much better than that of 100 mg (0.29, 0.49).
TBI (4 Gy) was administered as a single dose 1 h after injection of C61-LNP on Day 3 in the multiple dose regimen or on Day 1 in the single dose regimen.
C61-LNP was administered i.v. either as a single 80 mg/kg/day dose or as a multiple dose regimen daily for 3 or 9 consecutive days (80 mg/kg/day).
