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To evaluate the effects of single, multiple dose methotrexate (MTX) administration and salpingectomy on ovarian reserve in a rat model.
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To compare tubal patency by using hysterosalpingography (HSG) in women with unruptured ectopic tubal pregnancy who were treated with either single-dose or multiple-dose methotrexate (MTX) regimen.
multiple dose activated charcoal.
The role of low dose methotrexate (LDM) in potential serious toxicities remains unclear despite its common use.
The serum concentrations of methotrexate seen in the table, however, are frequently reached in high dose methotrexate administrations.
Doxorubicin, mitomycin, cisplatin, vinorelbine and high dose methotrexate are among the drugs showing some activity.
To assess whether success rate differs in single-dose versus multiple-dose administration of methotrexate (MTX) in medical management of unruptured ectopic pregnancies.
PEDF has multiple dose-dependent biological functions.
multiple doses, were included.
High-dose methotrexate causes kidney injury through multiple possible mechanisms; however, intratubular crystal precipitation is the most likely [ 8– 10].
Multiple-dose systemic treatment with methotrexate has been shown to be as effective as surgical treatment, whereas single-dose treatment is less effective.
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