Sentence examples for multiple dose levels from inspiring English sources
In a Phase I/II, clinical activity with minimal toxicity was observed at multiple dose levels in mutant BRAF tumors [9].
Although the study included multiple dose levels of LY, it was not designed to provide precise dose-response relationships because of limitations of sample size.
The arrays can be up to 3-dimensional, thereby allowing multiple dose levels, many individual patients, plus other key factors, as required.
An updated report on the phase I clinical trial (KEYNOTE-001) included the analysis of 411 melanoma patients treated across multiple dose levels.
Pharmacodynamic studies included in the daily continuous dosing schedule demonstrated significant inhibition of epithelial growth factor receptor (EGFR) phosphorylation and downstream members of MAPK pathway by immunohistochemistry at early, as well as multiple dose levels [3].
A randomized phase II study of multiple dose levels of CCI-779 in patients with advanced refractory renal cell carcinoma has shown antitumor activity and encouraging survival as well as drug tolerability [ 38].
The drug was well tolerated at each single or multiple dose level.
There were no clinically important findings in the morphology of the 12-lead ECG for individual subjects at each single and multiple dose level of SMT19969.
This increase from baseline for the ocular symptom of pain was, however, not statistically significant, even at the highest fractionated multiple dose level of 180 μg/ml (Fisher exact test: p = 0.0573).
This phase IIa, multicentre, randomized, placebo-controlled multiple-dose trial assessed the safety and tolerability of sotatercept at multiple dose-levels, and determined the effect of the drug on bone remodelling in MM patients with osteolytic lesions (ClinicalTrials.gov identifier: NCT00747123).
The EMA recommends a series of preclinical and clinical studies, including PD investigations in healthy volunteers, preferably at multiple-dose levels, with ANC as the primary endpoint and CD34+ cell count as a secondary parameter.
