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This article summarizes our experiences in the application of continuous subcutaneous insulin infusion (CSII) as a method of rapid desensitization therapy for diabetic patients with insulin allergy that was subsequently switched to a regimen of multiple-dose injections for long-term insulin therapy.
These data are consistent with that of the basal + mealtime versus premix comparison, where HbA1c and body weight change did not differ despite higher dose with the multiple injection regimen, but hypoglycaemia remained less frequent.
TBI (4 Gy) was administered as a single dose 1 h after injection of C61-LNP on Day 3 in the multiple dose regimen or on Day 1 in the single dose regimen.
Use of premix insulin was associated with a lower insulin dose and fewer injections than with the multiple injection regimen (Table 3).
This fact made the evaluation of a multiple dose regimen protocol surgically impracticable.
We also found a possible dose-effect relation between steroid dose and its effect on preventing laryngeal oedema after extubation and reintubation in the multiple dose regimen.
We found possible dose dependent effects in multiple dose regimens but not in single dose regimens.
Most youths (89%) were on either insulin pump or multiple daily injection regimens utilizing basal-bolus insulin dosing principles and carbohydrate counting for dietary management.
Although the studies were preliminary in nature, we have shown that this MNT as well as another MNT incorporating the same DTox-HMP-NLS modules but with α-melanocyte-stimulating hormone as the ligand module were not toxic to mice when administered either as a single injection at the maximum achievable dose or when administered in multiple dose regimens [6].
The immune responses following a single injection in the current study (which was performed before the results of the Step study became available) appear to compare favorably with responses in studies of multiple dose regimens of adenovectors alone or in combination with DNA plasmids, but there are some differences.
For those dependent on exogenous insulin, multiple insulin injection regimens or automatic insulin pumps were used.
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