Sentence examples for multiple dose group from inspiring English sources

The influence of 50 mg/kg multiple dose of genistein group was similar with that of 100 mg/kg multiple dose group.

No covariate, including total dose which was significantly higher in the multiple dose group (20 mg/kg versus 45 mg/kg, p ≤ 0.0001), influenced outcome in the adjusted model at 12 hours.

For the multiple dose group, blood samples were collected at 1 h before dose 4 (day 4) and at 24 h after dose 4 to dose 7 (day 5 to day 8).

Multiple dose groups for characterization of dose response relationships.

Our designs can be extended to multiple dose groups in a straightforward fashion.

Data analysis was done using nonlinear mixed-effect modeling (NONMEM version VI 2.0), which analyzed the PD data from multiple dose groups obtained simultaneously from different experiments.

Lipid levels measured at 1 h before dosing in the single dose groups and at 1 h before dose 3 in the multiple dose groups served as baseline values.

The gut microbiota was analysed in the multiple dose groups with minimal changes observed in the bacterial groups analysed except for total clostridia which were reduced to below the limit of detection by day 4 of dosing.

Adding to this number additional patients to compensate for a reasonably likely dropout rate (20%%), and assuming multiple dose groups (low, medium, high) with a placebo control comparator, results in a phase IIB study with approximately 500 subjects.

Because of the limited statistical power of the bioassay when group size is only about 50 animals per sex per dose, high doses are necessary to identify potential carcinogenic hazards, whereas multiple dose groups are used to characterize dose response relationships.

The reasons for the increased difference between the methods, as compared with the pure POC scenario, are the nonlinear exposure response relation that is more informed by multiple dose groups, and the inclusion of a follow-up observation adding more support to the drug effect.