Sentence examples for multiple dose applications from inspiring English sources

The time concentration profiles of MSF in humans were highly similar after single and multiple dose applications with maximal concentrations reached 20 to 40 min after application.

The dose dependency of AUC and Cmax after single and multiple dose applications were investigated by fitting the data to the power model ln AUC = alpha + beta ln(dose).

Except for the lowest dose, the total clearance was independent from dose (geometric means; 3.6 mg MSF = 13.79 l h−1, 7.2 mg MSF = 19.77 l h−1 and 10.8 mg MSF = 18.29 l h−1), and similar for single and multiple dose applications (18.76 l h−1, 18.89 l h−1 and 18.35 l h−1, respectively).

Considering the variability, the half-life after multiple dose application also did not appear to be dose related, although the geometric means decreased with increasing doses from 3.41 h to 3.06 h to 2.72 h, respectively.

These figures are similar to the AUCs within a multiple dose interval (steady-state, AUC 0,τ,ss) = 191.1 ng ml−1 h, 381.2 ng ml−1 h and 588.6 ng ml−1, respectively, for doses of 3.6, 7.2 and 10.8 mg MSF) indicating that no MSF metabolism was induced or inhibited after multiple dose application.

multiple dose activated charcoal.

RIPC: Remote Ischemic Preconditioning, SD: Single Dose, MD: Multiple Dose.

Nevertheless, the accuracy is sufficient for tribological high dose applications.

However, the poor aqueous solubility of DCU poses a challenge for in vivo dosing in a multiple dose situation.

Due to ease of administration in a multiple dose situation, oral dosing of the nanosuspension was examined initially.

Multiple dose groups for characterization of dose response relationships.