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Multiple doses and varied exposure durations are suggested to identify those genes clearly linked to toxic response.
Maximum plasma concentration was reached 4 h after single and multiple doses, and mean half-life on day 1 was approximately 6 h.
The plan was to enroll 128 volunteers aged between 18 and 55; the trial would first test a single dose, then multiple doses, and finally the combination of the drug with a meal.
Oral Lodamin was administered at multiple doses and durations: 15 mg/kg/day (for 7 days and 14 days of treatment) and 30 mg/kg dose (7 days).
Eribulin does not accumulate after multiple doses and is rapidly and extensively distributed [ 25].
However, these promising results should be further validated with multiple dosing and prolonged follow-up.
Toxicogenomics studies often profile gene expression from assays involving multiple doses and time points.
Then we treated the infected animals with multiple dosing and reduced the dosing interval to make the T > MIC longer.
These conclusions are based on studies involving multiple doses and time points in rodents, including results from the ED01.
Both datasets apply a study design that includes multiple doses and treatment durations across different assay systems.
Published dose-response curves of promoters of multistage carcinogenesis were selected that met the combined criteria of long study times, multiple doses, and low doses.
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