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To compare the efficacy of two starting protocols of multiple dose GnRH antagonists (GnRH-a).
To compare the efficacy of microdose GnRH agonist (GnRH-a) flare-up and multiple dose GnRH antagonist protocols in patients who have a poor response to a long luteal GnRH-a protocol.
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To compare follicular fluid concentrations of IGF-I, IGF-II, IGFBP-3, inhibin-B, VEGF, and AMH in women undergoing controlled ovarian hyperstimulation with a long-luteal GnRH agonist protocol or multiple-dose GnRH antagonist protocol.
Within Cetrorelix group patients who received CC had a significant shorter duration of stimulation and needed fewer ampoules as compared with patients in the same group who did not receive CC. Conclusions: A GnRH antagonist multiple dose protocol may be the protocol of choice for the treatment of poor responders.
Results: The use of GnRH antagonist in a multiple dose protocol gave a pregnancy rate of 14.28% which was in the range expected for patient with poor response, but with shorter treatment duration and with fewer ampoules of gonadotropins as compared with the use of a GnRH agonist protocol in a depot formulation.
multiple dose activated charcoal.
RIPC: Remote Ischemic Preconditioning, SD: Single Dose, MD: Multiple Dose.
Multiple dose groups for characterization of dose response relationships.
Both trials reported multiple dose adverse effects.
We found possible dose dependent effects in multiple dose regimens but not in single dose regimens.
To determine the efficiency of a single-dose and a multiple-dose protocol for GnRH antagonist administration.
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